Abstract Objective To investigate the status of vaccination in children with human immunodefciency virus (HIV) infection. Methods A questionnaire survey was performed in 148 children in Hunan province, China who were registered in China's Acquired Immune Deficiency Syndrome Comprehensive Response Information Management System up to December 31, 2016 and were aged Results Of the 148 children with HIV infection, there were 70 boys (47.3%) and 78 girls (52.7%); 140 children had an age of 3.8 (0.2-14.8) years at the time of confrmed diagnosis, and 8 children refused to answer this question. Mother-tochild transmission was found in 133 children (91.7%), blood transmission in 1 child (0.7%), and unknown in 14 children (9.5%). Of the 148 children, 129 (87.2%) received antiviral therapy and 19 (12.8%) did not receive such treatment. The vaccination rates of hepatitis B vaccine, bacille Calmette-Guérin vaccine, poliomyelitis live attenuated vaccine and diphtheria-pertussis-tetanus vaccine ranged from 70.9% to 77.7%, which was signifcantly lower than the national level (≥ 97%); the vaccination rates of the other vaccines in the National Immunization Program gradually decreased with age. No severe adverse effects were reported after vaccination. Conclusions Mother-to-child transmission is the main route of HIV infection in Chinese children. The diagnosis of children with HIV infection is signifcantly delayed, with low vaccination rates. Efforts should be made to strengthen early diagnosis, early treatment and vaccination in children with HIV infection, in order to improve their quality of life.
HU Yi-Yun,XIONG Ran,TANG Hou-Lin et al. An investigation of vaccination in children with human immunodeficiency virus infection[J]. CJCP, 2019, 21(3): 199-202.
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