Chinese Journal of Contemporary Pediatrics

Clinical study on low-dose rituximab maintenance therapy in children with primary nephrotic syndrome

Wen-Ting PENG, Xiao-Zhong LI

Chinese Journal of Contemporary Pediatrics, 2025, 27(8): 982-988. DOI: 10.7499/j.issn.1008-8830.2409131

生化指标	ALB [M(P ₂₅, P ₇₅), g/L]	IgG [( $x ¯$ ±s), g/L]	IgM [( $x ¯$ ±s), g/L]	TC [M(P ₂₅, P ₇₅), mmol/L]	TG [M(P ₂₅, P ₇₅), mmol/L]
治疗前 (n=70)	39.5(30.5, 42.6)	6.2±2.5	1.51±0.61	5.5(4.3, 6.5)	1.8(1.2, 2.9)
随访3个月 (n=70)	44.5(42.1, 46.5)	7.5±2.6	0.81±0.42	4.1(3.6, 4.7)	1.1(0.9, 1.5)
t/Z值	-5.154	-4.713	13.344	-5.637	-4.675
P值	<0.001	<0.001	<0.001	<0.001	<0.001
随访6个月 (n=70)	44.0(42.1, 46.1)	7.6±2.4	0.76±0.40	4.1(3.6, 4.6)	1.2(0.9, 1.6)
t/Z值	-4.852	-4.750	14.592	-5.372	-4.003
P值	<0.001	<0.001	<0.001	<0.001	<0.001
随访12个月 (n=66)	44.7(42.4, 45.8)	7.6±2.5	0.64±0.34	4.0(3.5, 4.7)	1.1(0.8, 1.6)
t/Z值	-4.839	-4.472	16.483	-0.492	-0.493
P值	<0.001	<0.001	<0.001	<0.001	<0.001
随访18个月 (n=53)	45.1(43.2, 46.7)	7.7±2.7	0.50±0.27	4.1(3.5, 4.6)	1.1(0.8, 1.5)
t/Z值	-5.613	-4.593	14.143	-5.360	-4.187
P值	<0.001	<0.001	<0.001	<0.001	<0.001
随访24个月 (n=38)	45.0(42.8, 47.1)	7.7±2.6	0.47±0.29	4.2(3.7, 4.7)	1.2(0.9, 1.6)
t/Z值	-4.344	-3.395	13.425	-4.815	-3.408
P值	<0.001	0.002	<0.001	<0.001	<0.001
随访36个月 (n=23)	45.1(43.2, 47.6)	7.2±2.5	0.48±0.24	4.2(3.8, 4.9)	1.1(0.7, 1.8)
t/Z值	-4.197	-2.119	11.903	-3.772	-2.677
P值	<0.001	0.046	<0.001	<0.001	0.007

表2 RTX治疗前与治疗后各时间点的指标变化比较

Other figure/table from this article