孤独症谱系障碍中性别差异的研究进展

doi:10.7499/j.issn.1008-8830.2411142

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Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, repetitive behaviors, and restricted interests. Studies have shown that it is more prevalent in males than females. Although this issue has attracted academic attention since the 20th century, the specific mechanisms underlying the gender differences in ASD remain unclear. This paper reviews the impact of gender differences in ASD, focusing on the female protective effect, DNA methylation, hormone levels, and clinical manifestations. It also discusses corresponding treatment options, particularly suggesting improvements in the diagnostic process, which is often overlooked, in order to provide valuable references for the clinical diagnosis and treatment of ASD.

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	JIANG Tong-Tong
	LI Xiu-Qiong
	ZHAO Ting-Ting
	LI Hong-Yu
	TANG Qiang

Key words： Autism spectrum disorder Gender difference Female protective effect Genetics Hormone level Epigenetics DNA methylation

Received: 26 November 2024

Cite this article:

JIANG Tong-Tong,LI Xiu-Qiong,ZHAO Ting-Ting et al. Advances in research on gender differences in autism spectrum disorders[J]. CJCP, 2025, 27(4): 480-486.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2411142 OR http://www.zgddek.com/EN/Y2025/V27/I4/480

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