[1]Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention:GINA executive summary[J]. Eur Respir J, 2008, 31(1):143-178.
[2]Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: Isaac phases one and three repeat multicountry crosssectional surveys[J]. Lancet, 2006, 368(9537):733-743.
[3]Brutsche MH, Downs SH, Schindler C, Gerbase MW,Schwartz J, Frey M, et al.Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: Sapaldia Cohort Study[J]. Thorax, 2006, 61(8):671-677.
[4]Harmanci K, Bakirtas A, Turktas I.Factors affecting bronchial hyperreactivity in asthmatic children[J]. J Asthma, 2008, 45(9):730-734.
[5]Pallasaho P, Ronmark E, Haahtela T, Sovijarvi AR, Lundback B. Degree and clinical relevance of sensitization to common allergens among adults: a population study in Helsinki, Finland[J]. Clin Exp Allergy, 2006, 36(4):503-509.
[7]Holt PG, Thomas WR. Sensitization to airborne environmental allergens: unresolved issues[J]. Nat Immunol, 2005, 6(10):957-960.
[8]Hospers JJ, Postma DS, Rijcken B, Weiss ST, Schouten JP. Histamine airway hyperresponsiveness and mortality from chronic obstructive pulmonary disease: a cohort study[J]. Lancet, 2000, 356(9238):1313-1317.
[9]National Heart, Lung and Blood Institute. Global strategy for asthma management and prevention. WHO/NHLBI Workshop Report, 2006:61-63.
[10]Van Den Berge M, Meijer RJ, Kerstjens HA, de Reus DM,Koeter GH, Kauffman HF, et al. Pc(20) adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than pc(20) methacholine[J]. Am J Respir Crit Care Med, 2001, 163(7):1546-1550.
[11]Byrne PM,Gauvreau GM,Brannan JD. Provoked models of asthma: what have we learnt?[J]. Clin Exp Allergy, 2009, 39(2): 181-192.
[12]Regamey N, Ochs M, Hilliard TN, Muhlfeld C, Cornish N, Fleming L. Increased airway smooth muscle mass in children with asthma, cystic fibrosis and non-cystic fibrosis bronchiectasis[J]. Am J Respir Crit Care Med, 2008, 177(8):837-843.
[14]Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, et al.Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of sever asthma[J].Am J Respir Crit Care Med, 2003, 169(6):703-711.
[15]Benayoun L, Druilhe A, Dombret MC, Aubier M,Pretolani M. Airway structural alterations selectively associated with severe asthma[J]. Am J Respir Crit Care Med, 2003, 167(10):1360-1368.
[16]Brown NJ, Salome CM, Berend N, Thorpe CW, King GG. Airway distensibility in asthmatic and healthy adults measured by forced oscillation technique[J]. Am J Respir Crit Care Med, 2007, 176(2):129-137.
[17]McClean M, Matheson MJ, McKay K, Johnson PRA, Rynell AC, Ammit AJ, et al. Low lung volume alters contractile properties of airway smooth muscle in sheep[J]. Eur Respir J, 2003, 22(1): 50-56.
[18]Cox G, Miller JD, McWilliams A, Fitzgerald JM, Lam S. Bronchial thermoplasty for asthma[J]. Am J Respir Crit Care Med, 2006, 173(9): 965-969.
[19]Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary diseas[J]. Proc Am Thorac Soc, 2004, 1(3):176-183.
[20]Kasahara K, Shiba K, Ozawa T, Okuda K, Adachi M. Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma[J]. Thorax, 2002, 57(3): 242-246.
[21]Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K, Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma[J]. Am J Respir Crit Care Med, 2003, 168(8):983-988.
[22]McParland BE,Macklem PT, Pare PD. Airway wall remodeling: friend or foe?[J]. J Appl Physiol, 2003, 95(1): 426-434.
[23]Simpson JL, Scott RJ, Boyle MJ, Gibson PG. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma[J]. Am J Respir Crit Care Med, 2005, 172(5): 559-565.
[24]Downie SR, Salome CM, Verbanck S, Thompson BR,Berend N, King GG. Ventilation heterogeneity is a major-determinant of airway hyperresponsiveness in asthma, independent of airway inflammation[J]. Thorax, 2007, 62(8): 684-689.
[25]Brightling CE, Bradding P, Symon FA, Holgate ST,Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma[J]. N Engl J Med, 2002, 346(22):1699-1705.
[26]Halvor S, Devendra K. Naturally occurring and lnducible t-regulatory cells modulating immune response in allergic asthma[J]. Am J Respir Crit Care Med, 2009, 180(3):211-225.