Abstract Objective To explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.Methods A retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.Results Compared with the control group, the case group had a longer length of stay in the PICU before infection (PPPPPPPConclusions Rational use of antibiotics is an effective measure to prevent MDR-KP sepsis.
Dass R, Deak NM, Barman H, et al. Empyema thoracis:analysis of 150 cases from a teriatry care centre in North East India[J]. Indian J Pediatr, 2011, 78(11):1371.
Chen LF, Anderson DJ, Paterson DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance[J]. Infect Drug Resist, 2012, 5:133-141.
[5]
Saidel-Odes L, Borer A. Limiting and controlling carbapenemresistant Klebsiella pneumoniae[J]. Infect Drug Resist, 2014, 7:9-14.
[6]
Bratu S, Landman D, Haag R, et al. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City:a new threat to our antibiotic armamentarium[J]. Arch Intern Med, 2005, 165(12):1430-1435.
[7]
Woodford N, Tierno PM, Young K, et al. Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A betalactamase, KPC-3, in a New York Medical Center[J]. Antimicrob Agents Chemother, 2004, 48(12):4793-4799.
[8]
Chia JH, Su LH, Lee MH, et al. Development of high-level carbapenem resistance in Klebsiella pneumoniae among patients with prolonged hospitalization and carbapenem exposure[J]. Microb Drug Resist, 2010, 16(4):317-325.
Borer A, Saidel-Odes L, Eskira S, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae[J]. Am J Infect Control, 2012, 40(5):421-425.
[15]
Wu D, Cai J, Liu J. Risk factors for the acquisition of nosocomial infection with carbapenem-resistant Klebsiella pneumoniae[J]. South Med J, 2011, 104(2):106-110.
[16]
Hussein K, Raz-Pasteur A, Finkelstein R, et al. Impact of carbapenem resistance on the outcome of patients' hospitalacquired bacteraemia caused by Klebsiella pneumoniae[J]. Hosp Infect, 2013, 83(4):307-313.
[17]
Chia JH, Su LH, Lee MH, et al. Development of high-level carbapenem resistance in Klebsiella pneumoniae among patients with prolonged hospitalization and carbapenem exposure[J]. Microb Drug Resist, 2010, 16(4):317-325.
[18]
Schechner V, Kotlovsky T, Kazma M, et al. Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae:who is prone to become clinically infected[J]. Clin Microbiol Infect, 2013, 19(5):451-456.
[19]
Borer A, Eskira S, Nativ R, et al. A multifaceted intervention strategy for eradication of a hospital-wide outbreak caused by carbapenem-resistant Klebsiella pneumoniae in Southern Israel[J]. Infect Control Hosp Epidemiol, 2011, 32(12):1158-1165.
[20]
Ciobotaro P, Oved M, Nadir E, et al. An effective intervention to limit the spread of an epidemic carbapenem-resistant Klebsiella pneumoniae strain in an acute care setting:from theory to practice[J]. Am J Infect Control, 2011, 39(8):671-677.
[21]
Munoz-Price LS, Hayden MK, Lolans K, et al. Successful control of an outbreak of Klebsiella pneumoniae carbapenemaseproducing K. pneumoniae at a long-term acute care hospital[J]. Infect Control Hosp Epidemiol, 2010, 31(4):341-347.
[22]
Kochar S, Sheard T, Sharma R, et al. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae[J]. Infect Control Hosp Epidemiol, 2009, 30(5):447-452.