Abstract Objective To investigate the changes and clinical significance of lymphocyte subsets in infants with bronchitis, bronchopneumonia, and bronchiolitis. Methods A total of 111 children with bronchitis, 418 children with bronchopneumonia, and 83 children with bronchiolitis were enrolled as disease groups, and 235 healthy children were enrolled as control group. Flow cytometry was applied to measure lymphocyte subsets. Results The bronchitis group had significantly lower numbers of T cells and CD3+CD8+ T cells than the control group (P+CD8+ T cells, a significantly higher number of T helper (Th) cells, and a significantly higher CD4/CD8 ratio than the control group, as well as a significantly higher number of Th cells than the bronchitis group. Compared with the children with mild bronchopneumonia, those with severe bronchopneumonia showed a reduction in T cells and an increase in B cells (P+CD8+ T cells than the control group (PPConclusions A low, disturbed cellular immune function and a high humoral immune function are involved in the development and progression of lower respiratory tract infectious diseases. The changes in immune function are related to the type and severity of diseases.
JIA Li-Ting,LI Jing,YUE Xiao-Xin et al. Changes in lymphocyte subsets in infants with common lower respiratory tract infectious diseases[J]. CJCP, 2016, 18(3): 229-232.
JIA Li-Ting,LI Jing,YUE Xiao-Xin et al. Changes in lymphocyte subsets in infants with common lower respiratory tract infectious diseases[J]. CJCP, 2016, 18(3): 229-232.
Chang AB, Yerkovich ST, Gibson PG, et al. Pulmonary innate immunity in children with protracted bacterial bronchitis[J]. J Pediatr, 2012, 161(4): 621-625. e1.
[3]
Palamaro L, Giardino G, Santamaria F, et al. Interleukin 12 receptor deficiency in a child with recurrent bronchopneumonia and very high IgE levels[J]. Ital J Pediatr, 2012, 38(1): 46-49.
[4]
García C, Soriano-Fallas A, Lozano J, et al. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis[J]. Pediatr Infect Dis J, 2012, 31(1): 86-89.
Shearer WT, Rosenblatt HM, Gelman RS, et al. Lymphocyte subsets in healthy children from birth through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study[J]. J Allergy Clin Immunol, 2003, 112(5): 973-980.
[7]
Jia L, Li J, Zhang Y, et al. Age-and sex-related reference intervals of lymphocyte subsets in healthy ethnic Han Chinese children[J]. Cytometry A, 2015, 87(12): 1116-1126.
[8]
Nguyen TH, Casale TB. Immune modulation for treatment of allergic disease[J]. Immunol Rev, 2011, 242(1): 258-271.
Cormier SA, Shrestha B, Saravia J, et al. Limited type I interferons and plasmacytoid dendritic cells during neonatal respiratory syncytial virus infectionpermit immunopathogenesis upon reinfection[J]. J Virol, 2014, 88(16): 9350-9360.
[14]
Rosenwasser LJ, Busse WW, Lizambri RG, et al. Allergic asthma and an anti-CD23 mAb (IDEC-152) Results of a phase I, single-dose, dose-escalating clinical trial [J]. J Allergy Clin Immunol, 2003, 112(3): 563-570.
