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Levels of blood free carnitine in preterm infants with different gestational ages and birth weights
QI Zhi-Ye, DUAN Jiang, WANG Qiong, YAO Qin, ZHONG Qing-Hua, ZHANG Cai-Ying, LIANG Kun
Chinese Journal of Contemporary Pediatrics ›› 2019, Vol. 21 ›› Issue (6) : 562-566.
PDF(1339 KB)
PDF(1339 KB)
Levels of blood free carnitine in preterm infants with different gestational ages and birth weights
Objective To examine blood concentrations of free carnitine (FC) in preterm infants with different gestational ages (GA) and birth weights (BW). Methods A total of 3 368 preterm infants were enrolled as subjects. According to GA, they were divided into extremely preterm birth (EPTB) group (GA <28 weeks; n=39), very preterm birth (VPTB) group (28 ≤ GA <32 weeks; n=405), moderately preterm birth (MPTB) group (32 ≤ GA < 34 weeks; n=507), and late preterm birth (LPTB) group (34 ≤ GA <37 weeks; n=2 417); according to BW, they were divided into extremely low birth weight (ELBW) group (BW <1 000 g; n=36), very low birth weight (VLBW) group (1 000 g ≤ BW < 1 500 g; n=387), low birth weight (LBW) group (1 500 g ≤ BW < 2 500 g; n=1 873), and normal birth weight (NBW) group (2 500 g ≤ BW <4 000 g; n=1 072). Blood concentrations of FC were measured between 72 hours and 7 days after birth. Results The EPTB and VPTB groups had significantly higher FC concentrations than the MPTB and LPTB groups (P < 0.05), and the MPTB group had significantly higher FC concentrations than the LPTB group (P < 0.05). The lower limit of the 95% medical reference range of FC increased with the reduction in GA. The ELBW and VLBW groups had significantly higher FC concentrations than the LBW and NBW groups (P < 0.05). The LBW group had significantly higher FC concentrations than the NBW group (P < 0.05). The lower limit of the 95% medical reference range of FC increased with the reduction in BW. Conclusions There is a significant increase in blood FC concentrations in very/extremely preterm infants and very/extremely low birth weight infants, and tend to decrease with the increases in GA and BW.
Free carnitine / Gestational age / Birth weight / Medical reference range / Preterm infant
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