Abstract Objective To explore the predictive significance of exhaled breath temperature (EBT) for airway inflammation changes in children with asthma. Methods A total of 60 children with asthma who met the inclusion criteria at the first visit were chosen as the asthma group, and 60 healthy children were selected as the control group. The EBT level was measured by the latest third-generation product (X-halo). The Childhood Asthma Control Test (C-ACT) score was recorded. EBT level and C-ACT score were compared between the asthma and control groups. At the subsequent visit one month later, the children were divided into well-controlled, partially-controlled, and uncontrolled groups according to their C-ACT scores. The EBT level and the FeNO level of the three groups were measured. EBT level and C-ACT score were compared among the three groups. The correlation between EBT and FeNO was analyzed. The data of initial diagnosis were reviewed, the EBT level and C-ACT score at the first visit were compared among the three groups, and the differences in EBT level and C-ACT score among the three groups at the second and first visits were evaluated. Results At the first visit, the asthma group had a significantly higher EBT and a significantly lower C-ACT score compared with the control group (P < 0.05). At the time of the subsequent visit, there was a significant difference in EBT level between the three groups, i.e., uncontrolled group > partially-controlled group > well-controlled group (P < 0.05), and there was also a significant difference in C-ACT score between the three groups, i.e., well-controlled group > partially-controlled group > uncontrolled group (P < 0.05). There were no significant differences in EBT level and C-ACT score at the first visit between the three groups. From the first visit to the subsequent visit, EBT level was significantly decreased in the well-controlled group (P < 0.05), but significantly increased in both partially-controlled group uncontrolled groups (P < 0.05); C-ACT score was significantly increased in the well-controlled and partially-controlled groups (P < 0.05), but significantly decreased in the uncontrolled group (P < 0.05). EBT and FeNO levels at the subsequent visit were positively correlated with each other in the uncontrolled group (P < 0.05). Conclusions EBT has predictive significance for the changes in airway inflammation in children with asthma.
XIAO Hou-Lan,CHEN Zhen-Hua,ZHANG Dong-Wu et al. Predictive significance of exhaled breath temperature for airway inflammation changes in children with asthma[J]. CJCP, 2019, 21(8): 806-811.
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