Abstract Objective To study the clinical features and treatment outcome of children with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorders (MOGAD). Methods A retrospective analysis was performed for the clinical data of 28 children with MOGAD (with 38 demyelinating episodes). Results Among the disease spectrums of 28 children with MOGAD, optic neuritis was the most common (12 cases, 43%), followed by acute disseminated encephalomyelitis (9 cases, 32%). Among the 38 demyelinating episodes in the 28 children, there were 29 cases (76%) of lesions in the acute stage on head magnetic resonance imaging (MRI), and most of these lesions were extensive or isolated subcortical white matter lesions. A total of 24 cases of spinal MRI results in the acute stage were recorded, among which there were 11 cases (46%) of spinal lesions. MRI abnormalities of the optic nerve were found in 18 cases of optic neuritis in the acute stage. Of the 28 children, 20 (71%) had an increase in white blood cell count in cerebrospinal fluid, with lymphocytes as the most common type of cells, and 3 children had an increase in protein. The titer of serum MOG antibody was 1:10-1:320 in the 28 children. All 28 children were administered with glucocorticoids, along with immunoglobulin in 18 children. The symptoms of 26 children (93%) were alleviated during follow-up, and only 2 children had neurological sequela of the optic function. Conclusions The clinical manifestations are diverse in children with MOGAD. Immunotherapy is effective and most children have a good prognosis.
ZHENG Ping,ZHANG Jian-Zhao,SUN Jing et al. Clinical features of children with myelin oligodendrocyte glycoprotein antibodyassociated disorders[J]. CJCP, 2020, 22(4): 368-373.
ZHENG Ping,ZHANG Jian-Zhao,SUN Jing et al. Clinical features of children with myelin oligodendrocyte glycoprotein antibodyassociated disorders[J]. CJCP, 2020, 22(4): 368-373.
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