宏基因组二代测序在疑难感染性疾病中的临床应用价值

doi:10.7499/j.issn.1008-8830.2110064

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Abstract Infectious diseases are commonly seen in clinical practice, and pathogen diagnosis is the key link in diagnosis and treatment; however, conventional pathogen detection methods cannot meet clinical needs due to time-consuming operation and low positive rate. As a new pathogen detection method, metagenomic next-generation sequencing (mNGS) has a wide detection range and can detect bacteria, viruses, fungi, parasites, rare pathogens, and even unknown pathogens. The technique of mNGS is unbiased and can rapidly, efficiently, and accurately obtain all nucleic acid information in test samples, analyze pathogens, and guide clinical diagnosis and treatment, thereby playing an important role in complicated infectious diseases. This article reviews the diagnostic advantages and clinical value of mNGS in bacterial, fungal, viral, and parasitic infections.

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	HAN Si-Yu

Key words： Infectious disease Metagenomic next-generation sequencing Pathogen detection Child

Received: 17 October 2021

Cite this article:

HAN Si-Yu. Clinical value of metagenomic next-generation sequencing in complicated infectious diseases[J]. CJCP, 2022, 24(2): 210-215.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2110064 OR http://www.zgddek.com/EN/Y2022/V24/I2/210

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