生物制剂在儿童感染SARS-CoV-2后多系统炎症综合征的应用研究进展

doi:10.7499/j.issn.1008-8830.2111005

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Abstract Multisystem inflammatory syndrome in children (MIS-C) is a type of hyperinflammatory symptoms similar to Kawasaki disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is commonly observed in children aged 8-10 years. Primary therapeutic medications for MIS-C are intravenous immunoglobulins and glucocorticoids. It has been reported that biologics, such as IL-1 receptor antagonist anakinra, IL-6 receptor antagonist tocilizumab, and TNF-α receptor antagonist infliximab, can be used as an option for critically ill patients. This article elaborates on the mechanism of action of the above biologics and discusses the efficacy and safety biologics in the treatment of MIS-C after SARS-CoV-2 infection, in order to provide methods for the treatment of MIS-C with severe symptoms.

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	CUI Han-Yu
	HU Chang-Ping

Key words： Multisystem inflammatory syndrome Severe acute respiratory syndrome coronavirus 2 Biologics Child

Received: 03 November 2021

Cite this article:

CUI Han-Yu,HU Chang-Ping. Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection[J]. CJCP, 2022, 24(2): 216-222.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2111005 OR http://www.zgddek.com/EN/Y2022/V24/I2/216

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