Abstract Objective To study the clinical efficacy of nasal synchronous intermittent mandatory ventilation (nSIMV) in premature infants with severe respiratory distress syndrome (RDS) after extubation. Methods A retrospective analysis on the clinical date of 126 premature infants with severe RDS who were hospitalized in the NICU between January 2013 and May 2015 was performed. Sixty-one premature infants who were hospitalized in the NICU between January 2013 and March 2014 received nasal continuous positive airway pressure (nCPAP) (nCPAP group) and 65 premature infants who were hospitalized in the NICU between April 2014 and May 2015 received nSIMV (nSIMV group). The blood gas analysis indexes, the rate of extubation failure, the causes of extubation failure and the incidence of complications were compared between the two groups. Results After 4 hours of treatment, the pH value, PaO2, SaO2 and oxygenation index in the nSIMV group were significantly higher than in the nCPAP group (P2 in the nSIMV group were significantly lower than in the nCPAP group (PPP>0.05), hypercapnia (6% vs 11%; P>0.05) and apnea (2% vs 13%; PP>0.05). After treatment, the incidence of abdominal distension in the nSIMV group was significantly lower than in the nCPAP group (9% vs 30%; PConclusions nSIMV for premature infants with severe RDS after extubation not only significantly improves lung function and reduces the rate of extubation failure, also results in a lower incidence of gastrointestinal side effects and does not increase the incidence of complications.
TAO Hai-Feng,TAO Min,CAI Na et al. Apllication of nasal synchronous intermittent mandatory ventilation in premature infants with severe respiratory distress syndrome after extubation[J]. CJCP, 2016, 18(1): 1-5.
TAO Hai-Feng,TAO Min,CAI Na et al. Apllication of nasal synchronous intermittent mandatory ventilation in premature infants with severe respiratory distress syndrome after extubation[J]. CJCP, 2016, 18(1): 1-5.
Zhou B, Zhai JF, Jiang HX, et al. Usefulness of DuoPAP in the treatment of very low birth weight preterm infants with neonatal respiratory distress syndrome[J]. Eur Rev Med Pharmacol Sci, 2015, 19(4): 573-577.
[2]
Howlett A, Ohlsson A, Plakkal N. Inositol in preterm infants at risk for or having respiratory distress syndrome[J]. Cochrane Database Syst Rev, 2015, 2: D366.
[3]
Armanian AM, Badiee Z, Heidari G, et al. Initial treatment of respiratory distress syndrome with nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure: a randomized controlled trial[J]. Int J Prev Med, 2014, 5(12): 1543-1551.
[4]
Rebello CM, Precioso AR, Mascaretti RS; Grupo Colaborativo do Estudo Brasileiro Multicêntrico de Surfactante. A multicenter, randomized, double-blind trial of a new porcine surfactant in premature infants with respiratory distress syndrome[J]. Einstein (Sao Paulo), 2014, 12(4): 397-404.
[5]
Chang HY, Claure N, D'ugard C, et al. Effects of synchronization during nasal ventilation in clinically stable preterm infants[J]. Pediatr Res, 2011, 69(1): 84-89.
Wang C, Guo L, Chi C, et al. Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis[J]. Crit Care, 2015, 19: 108.
[8]
Yilmaz O, Kahveci H, Zeybek C, et al. Inhaled iloprost in preterm infants with severe respiratory distress syndrome and pulmonary hypertension[J]. Am J Perinatol, 2014, 31(4): 321-326.
[9]
Nayeri FS, Esmaeilnia ST, Aminnezhad M, et al. Comparison of INSURE method with conventional mechanical ventilation after surfactant administration in preterm infants with respiratory distress syndrome: therapeutic challenge[J]. Acta Med Iran, 2014, 52(8): 596-600.
[10]
Paul S, Rao S, Kohan R, et al. Poractant alfa versus beractant for respiratory distress syndrome in preterm infants: a retrospective cohort study[J]. J Paediatr Child Health, 2013, 49(10): 839-844.
[11]
Ochiai R. Mechanical ventilation of acute respiratory distress syndrome[J]. J Intensive Care, 2015, 3(1): 25-33.
Pantalitschka T, Sievers J, Urschitz MS, et al. Randomised crossover trial of four nasal respiratory support systems for apnoea of prematurity in very low birthweight infants[J]. Arch Dis Child Fetal Neonatal Ed, 2009, 94(4): F245-F248.
[14]
Greenough A, Sharma A. What is new in ventilation strategies for the neonate?[J]. Eur J Pediatr, 2007, 166(10): 991-996.
[15]
Bai XM, Bian J, Zhao YL, et al. The application of nasal synchronized intermittent mandatory ventilation in primary apnea of prematurity[J]. Turk J Pediatr, 2014, 56(2): 150-153.
