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2011 Vol.  13 No.  9
Published: 2011-09-15
CLINICAL RESEARCH
EXPERIMENTAL RESEARCH
CLINICAL EXPERIENCE
CASE REPORT
REVIEW
691 YE Hong-Mao
Neonatal resuscitation guidelines Hot!
No abstract available
2011 Vol. 13 (9): 691-695 [Abstract] ( 4841 ) [HTML 1KB] [PDF 1139KB] ( 2129 )
696 LIU Cui-Qing, CUI Ze, XIA Yao-Fang, MA Li, FAN Li-Li
Randomized controlled study of targeted tidal volume ventilation for treatment of severe neonatal respiratory distress syndrome
OBJECTIVE: To evaluate the efficacy of targeted tidal volume ventilation in the treatment of severe neonatal respiratory distress syndrome (RDS). Methods: Eighty-four neonates with severe RDS between June 2008 and January 2010 were randomly assigned to 3 groups according to the ventilation mode: synchronized intermittent positive pressure ventilation plus volume guarantee (SIPPV+VG; n=31), high frequency oscillation ventilation (HFOV; n=23) and intermittent mandatory ventilation (IMV; n=30). The oxygenation status, the durations of oxygen exposure and ventilation and the incidence of complications were observed. Results: The oxygenation status (P/F and a/APO2) in the SIPPV+VG and the HFOV groups was improved significantly 12 hrs after ventilation (P＜0.05). While in the IMV group, the oxygenation status was not improved until 24 hrs after ventilation. The durations of oxygen exposure and ventilation in the SIPPV+VG and the HFOV groups were shorter than in the IMV group (P<0.05). The incidences of air leak syndrome and ventilation-associated pneumonia (VAP) were lower in the SIPPV+VG and the HFOV groups than in the IMV group (P<0.05). The incidence of severe intracranial hemorrhage in the HFOV group was higher than in the other two groups (P<0.05). Conclusions: Compared with IMV, SIPPV+VG and HFOV can improve the oxygenation status more quickly, shorten the ventilation duration and decrease the incidences of air leak syndrome and VAP in neonates with severe RDS.
2011 Vol. 13 (9): 696-699 [Abstract] ( 6537 ) [HTML 1KB] [PDF 944KB] ( 1914 )
711 TANG Ya-Nan, WEI Ling, TANG Yan-Yan, WANG Zhao-Hong, ZHANG Hui-Min, ZHAO Feng-Lin.
A follow-up of the survival and medical factors responsible for the termination of treatment in very or extremely low birth weight infants
OBJECTIVE: To study the outcomes of very or extremely low birth weight (VLBW/ELBW) infants born between 2000 and 2008 in a single NICU and the medical factors associated with the termination of treatment in some infants. METHODS: In this case control study, the clinical data of 148 VLBW/ELBW infants were retrospectively studied and the surviving infants were followed up. Both univariate analysis and multivariate logistic regression analysis were used to investigate the medical factors associated with terminating treatment in infants. RESULTS: Twenty infants (13.5%) failed to respond to the therapy and died in the hospital. Three infants (2.0%) died after discharge. Nineteen infants (12.8%) did not receive treatment due to decision of the guardian and died. Thirty infants (20.3%) were not followed up after discharge. Seventy-six infants (51.4%) survived, including 47 healthy infants, 2 cases of congenital diseases and 27 cases with poor prognosis. Multivariate logistic regression analysis showed there were 2 significant factors associated with terminating treatment: neonatal respiratory distress syndrome (P=0.030, OR=11.396, 95%CI 1.-102.701) and hospitalization periods (the year 2004-2006) (P=0.039, OR=9.869, 95%CI 1.118-87.140). CONCLUSIONS: The survival status of VLBW and ELBW infants needs to be improved. It is important to decrease the incidence of neonatal respiratory distress syndrome for decreasing the proportion of terminating treatment in the infants.
2011 Vol. 13 (9): 711-714 [Abstract] ( 4514 ) [HTML 1KB] [PDF 1035KB] ( 1157 )
740 DENG Xiao-Lu, YIN Fei, XIANG Qiu-Lian, LIU Chen-Tao, PENG Jing
Succinic semialdehyde dehydrogenase deficiency
Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessive disorder. This paper reports three cases of SSADH deficiency in infants. The infants developed the symptoms including developmental delay, intellectual disability, hypotonia, hyporeflexia and seizures. The electroencephalogram (EEG) showed background slowing and focal spike discharges in all of 3 patients. Head magnetic resonance imaging (MRI) demonstrated abnormalities in 2 patients, including basal ganglia damage and increased T2-weighted signal in bilateral cerebral peduncles. Urinary organic acid analysis with gas chromatography-mass spectrometry (GC-MS) revealed increased levels of 4-hydroxybutyrate (GHB) in 3 patients. SSADH deficiency was definitely diagnosed based on the clinical manifestations and the results of urinary organic acid analysis in the 3 children. It was concluded that early urine organic acid analysis is essential for children presenting with mental retardation, neuropsychiatric disturbance or epilepsy of unknown etiology.
2011 Vol. 13 (9): 740-742 [Abstract] ( 6868 ) [HTML 1KB] [PDF 446KB] ( 1683 )
747 LI Hong-Mei, HE Qing-Nan, LI Xiao-Yan, SHUAI Lan-Jun, ZHOU Pin, YI Zhu-Wen
Effects of huai qi huang on cytokines Th1, Th2 and Th17 and phagocytosis of alveolar macrophages in rats with asthma
OBJECTIVE: To study the effects of huai qi huang, a traditional Chinese medicine, on cytokines Th1, Th2 and Th17 levels and alveolar macrophage phagocytosis in asthmatic rats sensitized by ovalbumin (OVA). METHODS: Forty male Sprague-Dawley rats were randomly divided into five groups: normal control, untreated asthma, budesonide-treated, huai qi huang-treated and budesonide+huai qi huang-treated asthma (n=8 each). Asthma was induced by OVA sensitization and challenge. The levels of IL-4, IFN-γ and IL-17 in plasma and bronchoalveolar lavage fluid (BALF) were measured using ELISA. The phagocytosis of alveolar macrophages which were isolated and purified from BALF was evaluated by the colorimetric assay. RESULTS: The levels of IL-4 and IL-17 increased, in contrast, the IFN-γ level decreased in plasma and BALF in the untreated asthma group compared with those in the normal control group. The IFN-γ level in the huai qi huang-treated asthma group was higher than that in the untreated asthma group. The IFN-γ level increased and the IL-17 level decreased more significantly in the budesonide+huai qi huang-treated asthma group when compared with the budesonide and huai qi huang alone treatment groups. The phagocytosis of alveolar macrophages in the untreated asthma group was lower than that in the normal control group. Huai qi huang alone or combined with budesonide increased the phagocytosis of alveolar macrophages compared with the normal control, untreated asthma and budesonid-treated asthma groups. The levels of IFN-γ in plasma and BALF were positively correlated with the phagocytosis of alveolar macrophages. CONCLUSIONS: The levels of IL-4 and IL-17 increase and the IFN-γ level decreases in plasma and BALF, and the phagocytosis of alveolar macrophages decreases in asthmatic rats. Huai qi huang treatment may increase the IFN-γ expression in plasma and BALF and the phagocytosis of alveolar macrophages in asthmatic rats. There is a synergistic effect between huai qi huang and glucocorticoids.
2011 Vol. 13 (9): 747-750 [Abstract] ( 6014 ) [HTML 1KB] [PDF 936KB] ( 1279 )
CLINICAL RESEARCH
700 SU Ai-Ling, JIANG Li, GE Qin-Yu
Methylation of insulin-like growth factor binding protein 3 gene in neonates with intrauterine growth restriction
OBJECTIVE: To study the role of promoter methylation of insulin-like growth factor binding protein 3 (IGFBP3) in intrauterine growth restriction (IUGR). METHODS: Fifty neonates with IUGR and 30 healthy neonates were enrolled. The promoter methylation status of IGFBP3 in peripheral blood was evaluated by methylation-specific PCR (MSP) and high resolution melting (HRM) techniques. RESULTS: The complete methylation rate, partial methylation rate and non-methylation rate of IGFBP3 promoter in the IUGR group was 4% (2/50), 40% (20/50) and 56% (28/50), respectively. The partial methylation rate and non-methylation rate of IGFBP3 promoter in the control group were 13% (4/30) and 87% (26/30), respectively. There were significant differences in the promoter methylation rate of IGFBP3 between the two groups (P<0.01). CONCLUSIONS: The promoter methylation of IGFBP3 gene is associated with the pathogenesis of IUGR.
2011 Vol. 13 (9): 700-703 [Abstract] ( 5214 ) [HTML 1KB] [PDF 972KB] ( 1183 )
704 WU Xiang-Lan, LI Yue-Feng, ZHOU Bei-Yan, WU Li-Juan, WU Zhi-Jun
Effects of bifidobacteria on respiratory and gastrointestinal tracts in neonates receiving mechanical ventilation
OBJECTIVE: To study the effects of bifidobacterium on respiratory and gastrointestinal tracts in neonates receiving mechanical ventilation. METHODS: The eligible neonates were randomly assigned into two groups: observed (n=38) and control (n=43). The observed group was given bifidobacteria daily (one capsule per time, for 7 days) by nasal feeding from the next day after mechanical ventilation. Gastric pH, gastric bacteria colonization, feeding intolerance, weight gain, the incidence of ventilator-associated pneumonia (VAP), and the homology between the bacteria isolated from intra-gastric colonization with those causing VAP were observed. RESULTS: The incidence of gastric pH≤3 in the observed group was significantly higher than that in the control group 3, 5 and 7 days after mechanical ventilation (P＜0.01). The rate of gastric bacteria colonization in the observed group was significantly lower than that in the control group 5 and 7 days after mechanical ventilation (P＜0.01). The incidences of feeding intolerance and VAP in the observed group were significantly lower than those in the control group (P＜0.05, P＜0.01, respectively). The rate of homology of the bacteria isolated from intra-gastric colonization with those causing VAP in the observed group was significantly lower than that in the control group (P＜0.01). There were no significant differences in the weight gain between the two groups. CONCLUSIONS: Bifidobacterium can decrease gastric pH, gastric bacteria colonization and feeding intolerance, thus blocks the infection route "stomach-oropharynx-respiratory tract" indirectly and decreases the incidence of endogenous VAP in neonates receiving mechanical ventilation.
2011 Vol. 13 (9): 704-707 [Abstract] ( 5002 ) [HTML 1KB] [PDF 938KB] ( 1466 )
708 LI Yu-Mei, RAN Jie, LI Heng, YAN Chao-Ying
Risk factors for capillary leak syndrome in neonates
OBJECTIVE: To study the risk factors for capillary leak syndrome (CLS) in neonates. METHODS: The clinical data of 52 neonates with CLS (case group) were retrospectively reviewed. Fifty hospitalized neonates without CLS were used as the control group. The possible factors for the development of CLS were identified by univariate analysis. The independent risk factors for CLS were determined by multivariate logistic regression analysis. RESULTS: The univariate analysis showed that the incidences of hyperglycemia, respiratory distress syndrome (RDS), sepsis and cold injury syndrome in the case group were significantly higher than those in the control group (P<0.05). The logistic regression analysis showed that sepsis (OR=5.004, P=0.001), RDS (OR=3.880, P=0.013) and cold injury syndrome (OR=3.207, P=0.023) were the independent risk factors for the development of CLS. CONCLUSIONS: RDS, sepsis and cold injury syndrome are independent risk factors for CLS in neonates. Hyperglycemia may be associated with the development of CLS.
2011 Vol. 13 (9): 708-710 [Abstract] ( 6264 ) [HTML 1KB] [PDF 919KB] ( 1620 )
715 BAI Song-Ting, LU Jie, SHENG Guang-Yao, XU Song-Tao, XIE Lei, PENG Shao
Clinical efficacy of desmopressin in the treatment of mild hemophilia A in children
OBJECTIVE: To study the effects of desmopressin (DDAVP) on coagulation factor Ⅷ (FⅧ) and activated partial thromboplastin time (APTT) in children with mild hemophilia A. METHODS: Eighteen children with mild hemophilia A were enrolled. DDAVP (0.3 μg/kg?d) was injected intravenously for 5 days. Plasma FⅧ levels and APTT were measured before and after DDAVP treatment. RESULTS: In 16 of 18 children with mild hemophilia A, the bleeding symptoms, including the articular or musclar hematoma, were significantly alleviated as a result of DDAVP treatment. The plasma FⅧ levels increased significantly to (27±4)% and APTT was shortened to (66±10)s 60 minutes after the first dose of DDAVP treatment. The plasma FⅧ remained at the levels of 25%-30% during 3-4 days of DDAVP treatment. Five days after DDAVP treatment, the plasma FⅧ levels decreased ［(21±3)%］, and APTT was prolonged when compared with 1-4 days of DDAVP treatment. CONCLUSIONS: DDAVP treatment can increase plasma FⅧ levels and shorten APTT in children with mild hemophilia A. DDAVP is effective in the treatment of mild hemophilia A. The duration of DDAVP therapy for mild hemophilia A is recommended as 3 to 4 days.
2011 Vol. 13 (9): 715-717 [Abstract] ( 5350 ) [HTML 1KB] [PDF 969KB] ( 1191 )
718 WU Jun, CHENG Yi-Fei, ZHANG Le-Ping, LIU Gui-Lan, LU Ai-Dong, JIA Yue-Ping, WANG Bin
Clinical features and etiological spectrum in children with pancytopenia
OBJECTIVE: To study the clinical features and etiological spectrum of pancytopenia in children. METHODS: The clinical data of 174 children with pancytopenia between September 2003 and January 2010 were retrospectively reviewed. RESULTS: Pale face was the most common clinical manifestation (147 cases, 84.5%), followed by bleeding (87 cases, 50.0%) and fever (41 cases, 23.6%). Mild to moderate anemia, severe thrombocytopenia and mild leucopenia were common in complete blood count. Of the 174 children, pancytopenia was attributed to hematopoietic system diseases in 155 cases (89.1%) and non-hematopoietic system diseases (virus infections, systemic lupus erythematosus, hypersplenism and neuroblastoma) in 6 cases (3.4%). Aplastic anemia (91 cases, 52.3%) was the most common cause of pancytopenia, followed by myelodysplastic syndrome (37 cases, 21.3%), acute leukemia and other hematological tumours (11 cases, 6.3%) and hemophagocytic syndrome (6 cases, 3.4%). The cause of pancytopenia was not identified in 13 cases (7.5%). CONCLUSIONS: Anemia, bleeding and fever are the main clinical manifestations of pancytopenia in children. Pancytopenia is mostly caused by aplastic anemia in children. Myelodysplastic syndrome, hematological tumours and hemophagocytic syndrome are also the common causes.
2011 Vol. 13 (9): 718-721 [Abstract] ( 6840 ) [HTML 1KB] [PDF 998KB] ( 1763 )
722 TAN Li-Na, WEI Hai-Yan, ZHANG Yao-Dong, LU Ai-Lian, LI Ying
Relationship between serum ferritin levels and susceptibility to attention deficit hyperactivity disorder in children: a Meta analysis
OBJECTIVE: To study the possible relationship between serum ferritin levels and susceptibility to attention deficit hyperactivity disorder (ADHD) in children. METHODS: The papers relating to the relationship between serum ferritin levels and susceptibility to childhood ADHD were searched in the Database CBM, CNKI, VIP and PubMed. The Meta-analysis software RevMan 5.0 was used for the heterogeneity test and for the pooled OR calculation. Sensitivity and publication bias analysis were performed. RESULTS: Five control studies were included for the Meta analysis, including 258 cases of ADHD and 138 control cases. There was heterogeneity in the studies on the relationship between serum ferritin levels and susceptibility to childhood ADHD (P=0.003). So the studies were analyzed using the random-effect model. The pooled OR of serum ferritin levels and susceptibility to childhood ADHD was -23.09 (95%CI:-33.06-13.13; P<0.00001). The funnel plots did not indicate the existence of publication bias. CONCLUSIONS: The results from present Meta analysis can prove that serum ferritin levels are associated with susceptibility to childhood ADHD.
2011 Vol. 13 (9): 722-724 [Abstract] ( 6924 ) [HTML 1KB] [PDF 1038KB] ( 1764 )
725 CAI Yan-Hua, WANG Hua
Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy
OBJECTIVE: To study the effects of valproate sodium (VPA) on the level and axle of pituitary gonadotropin in adolescent girls with epilepsy. METHODS: Twenty-three adolescent girls with epilepsy aged from 8 to 14 years were treated with VPA for 1 year. The levels of serum pituitary gonadotropin including estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin and testosterone were measured before treatment and 3 months, 6 months and 1 year after treatment. RESULTS: The serum levels of estradiol, follicle-stimulating hormone, luteinizing hormone and prolactin in the children with epilepsy were not significantly different during the 1 year VPA treatment compared with pretreatment. However, the serum level of testosterone was reduced 1 year after treatment (0.4±0.3 ng/mL) compared with pretreatment (0.7±0.4 ng/mL) and 3 months after treatment (0.7±0.4 ng/mL) (P＜0.05). CONCLUSIONS: VPA treatment for 1 year does not increase serum levels of androgen in adolescent girls with epilepsy, suggesting that VPA is an ideal choice of treatment for the girls.
2011 Vol. 13 (9): 725-727 [Abstract] ( 4499 ) [HTML 1KB] [PDF 929KB] ( 1088 )
728 SHU Xiao-Li, CHENG Hai-Ying, YANG Ling-Rong, ZHANG Xu-Ping, ZHANG Yan-Yi, JIANG Mi-Zu
Value of protein array in the diagnosis of Helicobactor pylori infection in children
OBJECTIVE: To study the value of multiple Helicobacter pylori (H.pylori) antibody detection by protein array in the diagnosis of H.pylori infection in children. METHODS: Biopsy specimens obtained by gastroscopy from 120 children with digestive system symptoms were detected by rapid urease test (RUT) and modified Giemsa staining. Positivity in both RUT and Giemsa staining was the "gold criterion" of H.pylori infection. Serum samples of these patients were obtained and the antibodies against cytotoxin associated gene A protein (CagA), vacuolating toxin A (VacA), urease, heat shock protein 60 (Hsp60) and RdxA (nitroreductase) were detected by protein array technique. RESULTS: H.pylori infection was identified according to the "gold criterion" in 60 children. Compared with the "gold criterion", the goodness of fit and the coefficient of contingency in the diagnosis of H.pylori infection of the following four groups antibody detection were all statistically significant (P<0.001): anti-Ure antibody alone, anti-Ure antibody combined with anti-CagA antibody, anti-Ure antibody combined with anti-VacA antibody and anti-Ure antibody combined with anti-CagA and anti-VacA antibody. The sensitivity, specificity and accuracy of the detection of anti-Ure antibody combined with anti-CagA antibody for the diagnosis of H.pylori infection were 81.7%, 91.7% and 86.7%, respectively. The antibody detection showed a high positive predictive value (90.7%) and a high negative predictive value (83.3%). CONCLUSIONS: The antibody detection by protein array, especially the detection of anti-Ure antibody combined with anti-CagA antibody, is valuable in the diagnosis of H.pylori infection.
2011 Vol. 13 (9): 728-731 [Abstract] ( 5014 ) [HTML 1KB] [PDF 932KB] ( 1206 )
732 YI Ming-Ji, SUN Zhong-Yun, RAN Ni
Subjective quality of life in children with Tourette syndrome
OBJECTIVE: This study explored the subjective quality of life in children with Tourette syndrome (TS) in order to provide a basis for more effective interference of TS. METHODS: A total of 174 children with TS (≥8 years old) and 186 aged-matched healthy children as controls were enrolled. The subjective quality of life was investigated by a case-control study. RESULTS: The total score of subjective quality of life in the TS group (156.6±21.1) was lower than that in the control group (164.2±21.2; P<0.01). The scores of family life, school life, cognitive component, anxiety experience and depression experience (19.1±3.5 vs 20.7±3.0, 24.1±4.4 vs 26.6±3.2, 90.6±13.3 vs 97.9±15.3, 24.0±4.6 vs 25.1±3.1 and 23.8±4.4 vs 24.7±3.5) in the TS group were lower than those in the control group (P<0.05). The correlation analysis showed that the total score of subjective quality of life in children with TS was negatively related to the age, the course of disease, the severity of symptoms, the total score of child behavior problem and family conflict (r=-0.432, -0.213, -0.869, -0.137, -0.257; P<0.01), while it was positively related to family active-cultural orientation (r=0.084, P<0.01). The multiple step regression analysis indicated that the factors influencing the subjective quality of life in children with TS included the severity of symptoms, age, family conflict and family active-cultural orientation (β′=-0.787, -0.171, -0.109, 0.106; P<0.01). CONCLUSIONS: The subjective quality of life is not well in children with TS. It is important to control clinical symptoms and improve family environment for the improvement of the subjective quality of life in children with TS.
2011 Vol. 13 (9): 732-735 [Abstract] ( 4653 ) [HTML 1KB] [PDF 939KB] ( 1175 )
736 CHANG Shi, DENG Zhen-Han, DONG Chao, ZHANG Zhi-Peng, LIAO Hui-Jun, WANG Zhi-Ming
Clinical features and experience of diagnosis and treatment of thyroid neoplasm in children
OBJECTIVE: To study the clinical features, diagnosis and therapy of thyroid neoplasm in children. METHODS: A retrospective study was performed on 32 children with thyroid nodular who were underwent operation in Xiangya Hospital between January 2002 and December 2010. RESULTS: Of the 32 cases, there were 23 girls and 9 boys. Six cases were diagnosed as nodular Goiter adenoma and 26 cases were diagnosed as thyroid papillary carcinoma. B-ultrasonic examination showed a 100% accurate rate for the diagnosis of thyroid carcinoma. Fourteen children (44%) were proven to have concurrent Hashimoto′s thyroiditis. Twenty-two (69%) children with thyroid carcinoma were found to have lymph metastasis in the lateral neck. The children younger than 10 years showed a high rate of metastasis than those older one (94% vs 56%, P＜0.05). All 32 children received a surgical therapy. Subtotal thyroidectomy was performed on the 6 children with nodular Goiter adenoma. Total thyroidectomy (17 cases) or ipsilateral thyroidectomy (9 cases) was performed according to the stage of thyroid carcinoma. The surgical outcomes were followed up for 3 months to 9 years and no recurrence or death occurred. The development and growth were normal in the children. CONCLUSIONS: Childhood thyroid nodular attacks girls more than boys, and the frequency of malignancy is high. Hashimoto′s thyroiditis is a common concurrent disease. The incidence of local lymph metastasis is high in those younger than 10 years. The surgical therapy for thyroid neoplasm may lead satisfactory outcomes in children.
2011 Vol. 13 (9): 736-739 [Abstract] ( 5005 ) [HTML 1KB] [PDF 935KB] ( 1103 )
EXPERIMENTAL RESEARCH
743 LI Wen-Juan, CHEN Hui-Jin, QIAN Long-Hua, HE Ya-Fang, CHEN Guan-Yi
Effects of glial cell line-derived neurotrophic factor and memantine on long-term prognosis in neonatal rats with periventricular leukomalacia
OBJECTIVE: To evaluate the effects of glial cell line-derived neurotrophic factor (GDNF) and memantine on the longterm prognosis in neonatal rats with ischemia-induced periventricular leukomalacia (PVL). METHODS: Thirty-two 5-day-old neonatal rats were randomly divided into 4 groups: sham-operated, PVL, GDNF-treated and memantine-treated. PVL was induced by right carotid artery ligation and hypoxia in the PVL, GDNF-treated and memantine-treated groups. GDNF (100 μg/kg) or memantine (20 mg/kg) was injected in the two treatment groups immediately after PVL inducement. The weight of the rats was measured immediately before and after hypoxia ischemia (HI). Both of Morris water maze test and Rivlin inclined plane test were performed at 26 days old (21 days after HI). The values of the escape latency (EL) and swimming distance, and the maximum inclined plane degree which the rats could stand at least 5 seconds were compared among the four groups. RESULTS: The lower weight, the prolonged mean values of EL and swimming distance and the reduced maximum inclined plane degree were observed in the PVL group compared to those in the sham-operated, GDNF-treated and memantine-treated groups. There were no significant differences in the weight, the values of EI and swimming distance and the maximum inclined plane degree between the two treatment groups and the sham-operated group. CONCLUSIONS: The administration of either GDNF or memantine can markedly increase the abilities of spatial discrimination, learning and memory, and motor coordination, promote weight gain, and improve long-term prognosis in rats with PVL.
2011 Vol. 13 (9): 743-746 [Abstract] ( 5069 ) [HTML 1KB] [PDF 976KB] ( 1060 )
751 HE Chun-Zhi, LI Shuang-Jie
Effects of astragaloside on IGF-1 and associated protein expression in mice with acute viral myocarditis
OBJECTIVE: To study the effects of astragaloside on the expression of insulin-like growth factor-1 (IGF-1) and associated proteins in mice with viral myocarditis. METHODS: Sixty-five 4-week-old BALB/C mice were randomly divided into 5 groups: normal control, astragaloside control, untreated myocarditis, low-dose and high-dose astragaloside-treated myocarditis. The BALB/C mice in the later three groups were intraperitoneally injected with CVB3. The low-dose and high-dose astragaloside-treated myocarditis groups were given astragaloside of 0.07 and 0.6 mg/kg?d, respectively by intragastric administration. Fifteen days later, the samples of blood and muscular tissues were obtained. The expression of IGF-1 in plasma was measured using ELISA. The levels of IGF-1 and associated proteins in muscular tissues were measured by immunohistochemistry. The expression of IGF-1 mRNA in muscular tissues was examined by RT-polymerase chain reaction (RT-PCR). RESULTS: The expression of IGF-1 and associated proteins increased significantly in mice infected with CVB3. High-dose astragaloside treatment reduced the expression of IGF-1 and associated proteins, but low-dose astragaloside did not. CONCLUSIONS: High-dose astragaloside may reduce the expression of IGF-1 and associated proteins in mice with acute viral myocarditis, possibly thus providing protective effects on muscular tissues.
2011 Vol. 13 (9): 751-754 [Abstract] ( 5186 ) [HTML 1KB] [PDF 1244KB] ( 1095 )
CLINICAL EXPERIENCE
755 ZHOU Wei, YIN Lei, ZHOU Zheng-Yu
Etiology of childhood erythema nodosum in 23 cases
No abstract available
2011 Vol. 13 (9): 755-756 [Abstract] ( 4213 ) [HTML 1KB] [PDF 900KB] ( 1881 )
757 WU Xiao-Hong, HOU Yu
Diagnosis and treatment of congenital heart disease complicated by tracheal stenosis
No abstract available
2011 Vol. 13 (9): 757-759 [Abstract] ( 3664 ) [HTML 1KB] [PDF 909KB] ( 1113 )
760 ZHAO Xiao-Li, DU Li, PAN Kai-Li
Curative effect of antithymocyte globulin for aplastic anemia in 8 children
No abstract available
2011 Vol. 13 (9): 760-762 [Abstract] ( 3642 ) [HTML 1KB] [PDF 974KB] ( 1162 )
763 LIU Mei-Mei, XIAO Ji, DENG Li-Li, LIU Jian-Feng, WANG Jia-Zhen, WANG De-Ming
Curative effect of penehyclidine hydrochloride injection as an auxiliary therapy for serious pneumonia complicated by respiratory failure in children
No abstract available
2011 Vol. 13 (9): 763-764 [Abstract] ( 3602 ) [HTML 1KB] [PDF 912KB] ( 965 )
CASE REPORT
765 LU Shan, XING Yan, ZHOU Wei, WEI Ling
Childhood pulmonary heart disease: a report of 3 cases
No abstract available
2011 Vol. 13 (9): 765-766 [Abstract] ( 3043 ) [HTML 1KB] [PDF 904KB] ( 1026 )
REVIEW
767 MA Jing-Qiu, SHENG Xiao-Yang
Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms
No abstract available
2011 Vol. 13 (9): 767-771 [Abstract] ( 4083 ) [HTML 1KB] [PDF 960KB] ( 986 )
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