Relationship of cystatin C, fibrinogen, and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis
WANG Fang1 , ZHANG Ying-Hui2
Graduate School, Xinxiang Medical University, Xinxiang, Henan 453003, China
Abstract Objective To study the relationship of cystatin C (CysC), fibrinogen (Fbg), and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis (HSPN), and to explore their values. Methods The clinical data of 48 children diagnosed with HSPN by renal biopsy from January 2011 to January 2015 were reviewed. According to renal pathological grading, in the 48 children with HSPN, 12 had stage IIa or lower, 12 stage IIb, 17 stage IIIa, and 7 stage IIIb or higher. The latex-enhanced immunoturbidimetric assay, turbidimetric measurement, and end-point method were used to determine the levels of serum CysC, Fbg, and 24-hour urinary protein, respectively. Pearson and Spearman correlation analyses were used to test the correlations between the indices and between the indices and renal pathological grade. Results There were significant differences in the levels of serum CysC, Fbg, and 24-hour urinary protein between patients with different pathological grades (PPr=0.51, Pr=0.63, Pr=0.55, Pr=0.66, 0.64 and 0.68; respectively, PConclusions The levels of CysC, Fbg, and 24-hour urine protein can reflect the severity of renal injury, providing satisfactory prediction of the severity of renal injury in children with HSPN.
Key words ：
Cystatin C
Fibrinogen
24-Hour urinary protein
Henoch-Schönlein purpura nephritis
Child
Received: 10 December 2015
Cite this article:
WANG Fang,ZHANG Ying-Hui. Relationship of cystatin C, fibrinogen, and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis[J]. CJCP, 2016, 18(3): 233-237.
WANG Fang,ZHANG Ying-Hui. Relationship of cystatin C, fibrinogen, and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis[J]. CJCP, 2016, 18(3): 233-237.
URL:
http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2016.03.009 OR http://www.zgddek.com/EN/Y2016/V18/I3/233
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