OBJECTIVE: Retinopathy of prematurity (ROP) is one of important causes of childhood visual impairment and blindness. Many research has shown that low birth weight (BW) and low gestational age (GA) are primary risk factors for ROP. This paper aims at studying the other high risk factors involved in the development of ROP. METHODS: Sixty four preterm infants with and without ROP were divided into two groups: a ROP group and a control group without ROP (n=32 for each). The clinical data of the two groups were studied by case contrast study according to the paired design of GA and BW. Logistic regression analysis was done for 20 possible risk factors. RESULTS:The odds ratios of the duration of oxygen therapy (DOT), maximal PaO 2 (MaxPaO 2), pregnancy induced hypertension (PIH) and minimum pH value within the first 3 days of life (MinpH) were 2.764 , 2.175 , 1.935 and 2.417 respectively (P< 0.01 ). The logistic regression equation of the risk factors in preterm infants with ROP was Logit (P)=β 0+1.265 DOT+1.034 Max PaO 2+0.936 PIH-1.273 MinpH (χ 2= 25.634 , P< 0.01) . CONCLUSIONS: The long time of oxygen exposure, hyperoxia, PIH and acidosis are high risk factors in the development of ROP."/>
Risk Factors for Retinopathy of Prematurity
Department of Neonatology, Second Affiliated Hospital to Jinan University, Shenzhen, Guangdong 518020, China; 2. Department of Neonatology, Chonnam University Hospital, Kwangju, Korea
Abstract OBJECTIVE: Retinopathy of prematurity (ROP) is one of important causes of childhood visual impairment and blindness. Many research has shown that low birth weight (BW) and low gestational age (GA) are primary risk factors for ROP. This paper aims at studying the other high risk factors involved in the development of ROP. METHODS: Sixty four preterm infants with and without ROP were divided into two groups: a ROP group and a control group without ROP (n=32 for each). The clinical data of the two groups were studied by case contrast study according to the paired design of GA and BW. Logistic regression analysis was done for 20 possible risk factors. RESULTS:The odds ratios of the duration of oxygen therapy (DOT), maximal PaO 2 (MaxPaO 2), pregnancy induced hypertension (PIH) and minimum pH value within the first 3 days of life (MinpH) were 2.764 , 2.175 , 1.935 and 2.417 respectively (P< 0.01 ). The logistic regression equation of the risk factors in preterm infants with ROP was Logit (P)=β 0+1.265 DOT+1.034 Max PaO 2+0.936 PIH-1.273 MinpH (χ 2= 25.634 , P< 0.01) . CONCLUSIONS: The long time of oxygen exposure, hyperoxia, PIH and acidosis are high risk factors in the development of ROP.
