Abstract OBJECCTIVE: To study the changes of plasma vasoactive intestinal peptide (VIP) levels and the relationship of plasma VIP levels with feeding intolerance (FI) in preterm infants. METHODS: Plasma VIP concentrations were measured using radioimmunoassay in 53 preterm infants with FI 1, 4, 7 and 14 days after birth. Fifty-nine preterm infants without FI served as the control group. RESULTS: The fasting plasma concentrations of VIP in the FI group 1, 4 and 7 days after birth (129±46, 144±32 and 166±31 pg/mL respectively) were significantly lower than those in the control group (195±63, 197±31 and 205±34 pg/mL respectively) (P＜0.05). The increased plasma VIP concentrations were associated with the increased gestational age, age in days and enteral feeding volume in the FI group. By 14 days, the plasma concentrations of VIP in the FI group (198±41 pg/mL) were similar to those in the control group (202±48 pg/mL) (P>0.05). The younger the infant′s gestational age, the more prolonged the FI. Plasma levels of VIP on day 1 of life in the FI group were negatively correlated with the duration of FI (r=-0.799, P＜0.05). CONCLUSIONS: Plasma levels of VIP might be related to the development of FI in preterm infants and might serve as a predictor of FI.
XU Jing,HUANG Run-Zhong,HUANG Jian-Wei et al. Relationship between plasma levels of vasoactive intestinal peptide and feeding intolerance in preterm infants[J]. 中国当代儿科杂志, 2011, 13(6): 451-454.
XU Jing,HUANG Run-Zhong,HUANG Jian-Wei et al. Relationship between plasma levels of vasoactive intestinal peptide and feeding intolerance in preterm infants[J]. CJCP, 2011, 13(6): 451-454.
［3］Clark RH, Wagner CL, Merritt RJ, Bloom BT, Neu J, Young TE, et al. Nutrition in the neonatal intensive care unit: how do we reduce the incidence of extrauterine growth restriction?［J］. J Perinatol, 2003, 23(4):337-344.
［4］Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ. Structure, expression and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene［J］．Proc Natl Acad Sci USA,1995, 92(7): 2939-2943.
［5］Nylander O, Sjoblom M. Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum［J］. Acta Physiol (Oxf), 2007, 189(4): 325335.
［6］Ekblad E, Bauer AJ.Role of vasoactive intestinal peptide and inflammatory mediators in enteric neuronal plasticity［J］．Neurogastroenterol Motil, 2004, 16（Suppl 1）:123-128.
［7］van Haver ER, de Vooght L, Oste M, Sangild PT, Thymann T, Weyns AL, et al. Postnatal and diet-dependent increases in enteric glial cells and VIP-containing neurones in preterm pigs［J］. Neurogastroenterol Motil, 2008, 20(9):1070-1079.
