Abstract OBJECTIVE: To study changes of serum S100B protein level in preterm infants with brain damage and its role. METHODS: Forty-seven preterm infants were classified into 3 groups based on the results of brain ultrasound and MRI: brain white matter damage (WMD; n=13), brain but not white matter damage (non-WMD; n=14) and control (no brain damage; n=20). Blood samples were collected within 24 hrs, 72 hrs and 7 days after birth. S100B protein level was measured using ELISA. RESULTS: Serum levels of S100B in the WMD and non-WMD groups were significantly higher than in the control group within 24 hours, 72 hours and 7 days after birth (P<0.05). More increased serum S100B levels were observed in the WMD group compared with the non-WMD group (P<0.05). CONCLUSIONS: Serum S100B protein level increases in preterm infants with brain damage within 7 days after birth, suggesting that it may be used as an early sensitive marker for the diagnosis of brain damage, especially WMD.
XIE Li-Juan,LI Hua-Jun,ZHU Jian-Xing. Relationship between serum S100B protein level and brain damage in preterm infants[J]. 中国当代儿科杂志, 2012, 14(07): 485-488.
XIE Li-Juan,LI Hua-Jun,ZHU Jian-Xing. Relationship between serum S100B protein level and brain damage in preterm infants[J]. CJCP, 2012, 14(07): 485-488.
［5］Debillon T, N′Guyen S, Muet A, Quere MP, Moussaly F, Roze JC. Limitations of ultrasonography for diagnosing white matter damage in preterm infants［J］. Arch Dis Child Fetal Neonatal Ed, 2003, 88(4): F275-F279.
［6］Schafer BW, Heizmann CW. The S100 family of EF-hand calcium-binding protein: functions and pathology［J］. Trends Biochem Sci, 1996, 21(4): 134-140.
［7］Nagdyman N, Grimmer I, Scholz T, Muller C, Obladen M. Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia［J］. Pediatr Res, 2003, 54(2): 270-275.
