儿童T淋巴母细胞淋巴瘤采用白血病方案治疗的预后分析

doi:10.7499/j.issn.1008-8830.2311060

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Abstract Objective To investigate the prognosis of childhood T-lymphoblastic lymphoma (T-LBL) treated with acute lymphoblastic leukemia (ALL) regimen and related influencing factors. Methods A retrospective analysis was performed for the prognostic characteristics of 29 children with T-LBL who were treated with ALL regimen (ALL-2009 or CCCG-ALL-2015 regimen) from May 2010 to May 2022. Results The 29 children with T-LBL had a 5-year overall survival (OS) rate of 84%±7% and an event-free survival (EFS) rate of 81%±8%. The children with B systemic symptoms (unexplained fever >38°C for more than 3 days; night sweats; weight loss >10% within 6 months) at initial diagnosis had a lower 5-year EFS rate compared to the children without B symptoms (P<0.05). The children with platelet count >400×109/L and involvement of both mediastinum and lymph nodes at initial diagnosis had lower 5-year OS rates (P<0.05). There were no significant differences in 5-year OS and EFS rates between the children treated with CCCG-ALL-2015 regimen and those treated with ALL-2009 regimen (P>0.05). Compared with the ALL-2009 regimen, the CCCG-ALL-2015 regimen reduced the frequency of high-dose methotrexate chemotherapy and the incidence rate of severe infections (P<0.05). Conclusions The ALL regimen is safe and effective in children with T-LBL. Children with B systemic symptoms, platelet count >400×109/L, and involvement of both mediastinum and lymph nodes at initial diagnosis tend to have a poor prognosis. Reduction in the frequency of high-dose methotrexate chemotherapy can reduce the incidence rate of severe infections, but it does not affect prognosis.

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	Articles by authors
	HOU Shu-Min
	SHAO Jing-Bo
	LI Hong
	ZHANG Na
	ZHU Jia-Shi
	WANG Dan
	FU Pan

Key words： T-lymphoblastic lymphoma Treatment Prognosis Child

Received: 13 November 2023

Cite this article:

HOU Shu-Min,SHAO Jing-Bo,LI Hong et al. Prognostic analysis of childhood T-lymphoblastic lymphoma treated with leukemia regimen[J]. CJCP, 2024, 26(5): 469-475.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2311060 OR http://www.zgddek.com/EN/Y2024/V26/I5/469

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