Relationship between serum erythropoietin levels and brain injury in preterm infants
CHEN Guang-Fu1, LI Hui-Tao2, HUANG Jin-Jie3, WANG Zhang-Xing4, LI Yun1, YANG Chuan-Zhong2, WU Ben-Qing3, LIU Wen-Lan1, LIU Li-Hui1, KONG Qi1, LIU Rong-Tian1
Department of Pediatrics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, China
Abstract Objective To study the relationship between the levels of erythropoietin (EPO) in serum and brain injury in preterm infants. Methods Three hundred and four preterm infants (gestational age: 28-34 weeks) born between October 2014 and September 2015 were enrolled in this study. Brain injury was diagnosed using cerebral ultrasound and MRI. The levels of EPO, S100 protein, neuron-specific enolase (NSE) and myelin basic protein (MBP) in serum were detected using ELISA. To compare the incidence of brain injury in different serum EPO levels in preterm infants, and the relationship between brain injury and serum EPO levels was analyzed. Results The incidence rate of brain injury in preterm infants was 41.1% (125/304). The incidence rate of brain injury in the low EPO level group was significantly higher than that in the middle-high EPO level groups (P P P Conclusions There is a higher incidence rate of brain injury in preterm infants with lower serum EPO levels. The serum EPO levels may be correlated with brain injury in preterm infants.
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