CJCP
  中文版
  English Version
 
 
2014 Vol.  16 No.  9
Published: 2014-09-15
CLINICAL RESEARCH
EXPERIMENTAL RESEARCH
CLINICAL EXPERIENCE
CASE REPORT
REVIEW
CLINICAL RESEARCH
873 ZHANG Hong-Xi, YANG Hui-Ping, LAI Can, HE Jing, YE Jing-Jing, FU Jun-Fen
Diagnostic value of ultrasonographic examination for hepatic steatosis in obese children Hot!

Objective To evaluate the sensitivity and specificity of hepatic ultrasonography（US) for the diagnosis of hepatic steatosis in obese children, using 1H magnetic resonance spectroscopy（1H MRS) as the reference standard.Methods A total of 162 obese children with age of 10.5±2.2 years and BMI of 28±4 were enrolled in this study. They accepted hepatic US and 1H MRS examinations. The sensitivity, specificity, positive predictive value（PPV) and negative predictive value（NPV) of US were calculated for the overall presence of hepatic steatosis by comparison with 1H MRS results. Results Using quantitative criteria of liver fat content（LFC) >5% determined by 1H MRS, 95 children(58.6%) were diagnosed as having hepatic steatosis. The sensitivity and specificity of US in diagnosing steatosis were 91.6%（87/95) and 50.7%（34/67) respectively, with PPV of 72.5%（87/120), and NPV of 81.0%（34/42). Considerable overlap in LFC measured by 1H MRS was observed between different grades from US findings: absent（LFC interquartile range:1.3%-3.9%), mild（2.4%-10.7%), moderate（7.1%-20.2%) and severe（7.6%-28.8%) steatosis. Conclusion The US can yield a high sensitivity and low specificity in the diagnosis of hepatic steatosis in obese children, suggesting it can be used as a screening tool for hepatic steatosis. To improve diagnostics, 1H MRS is needed to determine LFC.
2014 Vol. 16 (9): 873-877 [Abstract] ( 5360 ) [HTML 1KB] [PDF 1272KB] ( 1345 )
878 ZHANG Ming-Chen, LI Ming, MAO Jiang-Feng, YI Li-Duo-Si
Relationship between serum uric acid level and metabolic syndrome in Uygur children and adolescents with overweight or obesity
Objective To study the relationship between serum uric acid（SUA) level and metabolic syndrome（MS) in Uygur children and adolescents with overweight or obesity.Methods A total of 173 Uygur children or adolescents who were either overweight or obese and 200 controls with normal body weight were included in the study. Body weight, height, waist circumference, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, and SUA were measured. Results The overweight and obesity groups had significantly higher SUA levels（235±42 and 285±42 μmol/L respectively) than the control group（199±32 μmol/L; P<0.01). The subjects with SUA levels of 300-349 μmol/L and ≥350 μmol/L had significantly higher incidence of MS, overweight/obesity, hypertension and dyslipidemia than those with SUA levels of <250 μmol/L and 250-299 μmol/L（P<0.01). There were significant differences in SUA levels between groups with different MS components. SUA level was significantly increased in groups with more MS components（P<0.01). Every 1 kg/m2 increment in body mass index（BMI) was associated with 5.74 μmol/L increase in SUA level, according to a multivariate regression analysis.Conclusion Uygur children and adolescents who are either overweight or obese have higher SUA levels than those with normal body weight. The incidence of MS and its components rises with increasing SUA level. BMI has a positive relationship with SUA.
2014 Vol. 16 (9): 878-882 [Abstract] ( 7198 ) [HTML 1KB] [PDF 1139KB] ( 1189 )
883 XIONG Fei, YANG Fan, YANG Su-Fei, WU Kang-Min
Relationship between serum 25-hydroxyvitamin D and bone mineral density in children under 7 years old
Objective To evaluate the endogenous vitamin D level and its correlation with bone mineral density（BMD) in children under 7 years old. Methods Totally 6 838 children who visited the Growth and Development Clinic due to "growth retardation, night terrors, hyperhidrosis, and dysphoria" were enrolled in the study. Serum 25-hydroxyvitamin D [25(OH)D] level was measured by chemiluminescence, whereas individual BMD was measured by quantitative ultrasound. Results Among all subjects, serum 25(OH)D level was 34±14 ng/mL, and the Z value of BMD was -0.49±0.54. With increasing age, serum 25(OH)D level and BMD decreased gradually（P<0.01), and the detection rates for vitamin D deficiency and low BMD increased gradually（P<0.01). Compared with those with sufficient vitamin D, children with vitamin D deficiency had a significantly lower BMD（P<0.01) and a significantly higher detection rate for low BMD（P<0.01). 25-(OH)D level showed a positive linear correlation with BMD in children with vitamin D deficiency（P<0.01). Conclusion Preschool and school-age children have severer vitamin D deficiency than infants.Vitamin D level may be correlated with BMD within a certain range.
2014 Vol. 16 (9): 883-886 [Abstract] ( 6415 ) [HTML 1KB] [PDF 1150KB] ( 1570 )
887 MA Liang, MENG Ling-Dan, ZHENG Chun-Hui, ZHAO Fang-Qin, CAO Ai-Hua
High-risk factors for quality of general movements in infants
Objective To investigate the high-risk factors for the quality of general movements（GMs), which has a predictive value for brain dysfunction in infants.Methods A total of 618 infants in the stage of writhing movements and 539 infants in the stage of fidgety movements were selected separately for the evaluation of GMs. The high-risk factors for the quality of GMs in infants were analyzed by ANOVA, chi-square test, and multivariate logistic regression. Results Multivariate logistic regression analysis showed that the factors significantly associated with the quality of GMs in the stage of writhing movements were gestational age（OR=0.762, P<0.001), birth weight（OR=0.264,P<0.001), severe asphyxia（OR=2.445, P=0.012), and intrauterine distress（OR=4.865, P<0.001); the factors significantly associated with the quality of GMs in the stage of fidget movements were gestational age（OR=0.786, P=0.003), birth weight（OR=0.217, P<0.001), severe asphyxia（OR=3.765, P=0.001), and hyperbilirubinemia（OR=2.640, P=0.028).Conclusion Low gestational age, low birth weight, severe asphyxia, hyperbilirubinemia and intrauterine distress are high-risk factors for abnormal GMs in infants, and early screening and intervention should be performed to reduce the incidence of abnormal nervous system sequelae.
2014 Vol. 16 (9): 887-891 [Abstract] ( 5611 ) [HTML 1KB] [PDF 1176KB] ( 1411 )
892 ZHOU Ke-Ying, XIAO Zhi-Hui, CHEN Yan-Zhao, ZHANG Zhao-Xia, LIU Zhi-Ping, YANG Chun-He, GAO Mei-Hao
Clinical features and risk factors of co-morbid tic disorder in children with attention deficit hyperactivity disorder
Objective To study the clinical features and risk factors of co-morbid tic disorder（TD) in children with attention deficit hyperactivity disorder（ADHD). Methods A total of 312 children with ADHD were involved in this study. Subtypes of co-morbid TD, incidences of TD in different subtypes of ADHD（ADHD-I, ADHD-HI and ADHD-C) were observed. Thirteen potential factors influencing the comorbidity rate of TD in ADHD were evaluated by univariate analysis and multiple logistic regression analysis. Results Forty-two of 312 children with ADHD suffered from co-morbid TD（13.5%). Comorbidity rate of TD in children with ADHD-C（24.1%) was significantly higher than in those with ADHD-HI（10.9%) and ADHD-I（8.8%)（P<0.05). There were 21 cases（50.0%) of transient TD, 12 cases（28.6%) of chronic TD, and 9 cases（21.4%) of Tourette syndrome. The univariate analysis revealed 6 factors associated with comorbidity: addiction to mobile phone or computer games, poor eating habits, infection, improper family education, poor relationship between parents and poor relationship with schoolmates. Multiple logistic analysis revealed two independent risk factors for comorbidity: improper family education（OR=7.000, P<0.05) and infection（OR=2.564,P<0.05). Conclusion The incidence of co-morbid TD in children with ADHD is influenced by many factors, and early interventions should be performed based on the main risk factors.
2014 Vol. 16 (9): 892-895 [Abstract] ( 7027 ) [HTML 1KB] [PDF 1133KB] ( 1564 )
896 LIU Wen-Long, ZHAO Xu, TAN Jian-Hui, WANG Juan
Attention characteristics of children with different clinical subtypes of attention deficit hyperactivity disorder
Objective To explore the attention characteristics of children with different clinical subtypes of attention deficit hyperactivity disorder（ADHD) and to provide a basis for clinical intervention.Methods A total of 345 children diagnosed with ADHD were selected and the subtypes were identified. Attention assessment was performed by the intermediate visual and auditory continuous performance test at diagnosis, and the visual and auditory attention characteristics were compared between children with different subtypes. A total of 122 normal children were recruited in the control group and their attention characteristics were compared with those of children with ADHD. Results The scores of full scale attention quotient（AQ) and full scale response control quotient（RCQ) of children with all three subtypes of ADHD were significantly lower than those of normal children（P<0.01). The score of auditory RCQ was significantly lower than that of visual RCQ in children with ADHD-hyperactive/impulsive subtype（P<0.05). The scores of auditory AQ and speed quotient（SQ) were significantly higher than those of visual AQ and SQ in three subtypes of ADHD children（P<0.01), while the score of visual precaution quotient（PQ) was significantly higher than that of auditory PQ（P<0.01). No significant differences in auditory or visual AQ were observed between the three subtypes of ADHD. Conclusion The attention function of children with ADHD is worse than that of normal children, and the impairment of visual attention function is severer than that of auditory attention function. The degree of functional impairment of visual or auditory attention shows no significant differences between three subtypes of ADHD.
2014 Vol. 16 (9): 896-900 [Abstract] ( 6054 ) [HTML 1KB] [PDF 1215KB] ( 1423 )
901 ZHU Ming-Zhe, ZHU Xiao-Jing, DU Jian-Er, ZHANG Xiao-Lei
Efficacy of short-term educational intervention for parents of preschool children with anxiety
Objective To study the efficacy of short-term educational intervention for parents of preschool children with anxiety.Methods Forty-nine children with Spence Preschool Anxiety Scale（SPAS) scores of ≥48 were randomly divided into intervention and control groups. The children's parents in the intervention group received a collective curriculum on children's anxiety management six times, while the control group was only followed up. All children were evaluated for anxiety by the SPAS 3 and 6 months later, and then the results were compared between the two groups.Results The test was completed in 21 cases of the intervention group and 22 cases of the control group. At month 3,the intervention group had a significantly lower percentage of children with SPAS scores of ≥48 than the control group(62% vs 91%; P<0.05), and this percentage was also significantly lower in the intervention group than in the control group at month 6（52% vs 82%; P<0.05). At month 3, the intervention group had a significantly reduced mean SPAS score, which was significantly lower than that of the control group（69±12 vs 81±12; P<0.01). At month 6, both groups showed significant decreases in SPAS score, but still the SPAS score was significantly lower in the intervention group than in the control group（65±13 vs 78±13; P<0.01). Conclusion Early short-term education for parents can relieve their preschool children's anxiety effectively, but the long-term effect needs to be evaluated by follow-up.
2014 Vol. 16 (9): 901-904 [Abstract] ( 5400 ) [HTML 1KB] [PDF 1149KB] ( 1164 )
905 FU Xiao-Yan, XIE Xiao-Tian, MEI Zhu
Effect of structural family therapy on family structure and function in children with hematological tumors
Objective To explore the effect of structural family therapy（SFT), which refers to the application of the theory and technology of SFT for improving the internal family environment of pediatric patients through reorganization of the family roles, tasks, and boundaries, on the family structure and function in children with hematological tumors.Methods Forty children with hematological tumors were randomly divided into SFT and control groups（n=20 each). The control group received conventional chemotherapy. The SFT group received SFT by a trained therapist in addition to conventional chemotherapy; the family of each patient received SFT four times（once every two weeks). Both groups were assessed by the Family Assessment Device（FAD) and Family Environment Scale-Chinese Version（FES-CV) on admission and one month after the end of SFT.Results After treatment, the SFT group showed significant decreases in all factor scores of FAD（P<0.05); the SFT group had significantly lower scores of problem solving, communication, roles, affective involvement, behavior control, and general functioning than the control group（P<0.05). In addition, the SFT group had significantly increased FES-CV scores of cohesion, emotional expression, intellectual-cultural orientation, and active-recreational orientation and a significantly decreased score of conflict after treatment（P<0.05), and the SFT group was significantly superior to the control group in terms of these items（P<0.05).Conclusion SFT could promote beneficial family changes in children with hematological tumors by improving the family function and internal environment, which would increase the long-term chemotherapy compliance of these children and their parents.
2014 Vol. 16 (9): 905-909 [Abstract] ( 6140 ) [HTML 1KB] [PDF 1232KB] ( 1576 )
910 QI Zhi-Ye, DUAN Jing, ZHANG Quan, CAO Zhi-Lan, DAI Mei, XIONG Jing-Jing, MO Ya-Xiong, LU Ping
Epidemiological survey of childhood asthma in Kunming City, China
Objective To investigate the prevalence of childhood asthma, and to find the distribution characteristics, precipitating factors, diagnosis and treatment status, and to provide scientific data for improving the prevention and management of asthma in children in Kunming City, China.Methods Children were selected by random cluster sampling. A standardized preliminary questionnaire was used for screening out possible patients in the survey. Diagnosis of asthma was confirmed by diagnostic criteria in suspected asthmatic children. Asthmatic children were further asked for past diagnosis and treatment with the questionnaire of asthma in children. Results The total asthma incidence rate was 1.40%. The prevalence of asthma in male and female children was 1.89% and 0.88% respectively（P<0.05). Children aged 0-5 years old had a higher prevalence of asthma（1.69%) than that of school-age children（6-14 years old, 1.21%). In all asthmatic children, 51.3% were previously diagnosed with classical asthma or cough variant asthma, 26.0% were suffered attacks from December to February, and 54.0% were suffered attacks at midnight or dawn. Respiratory tract infection（87.3%) was the most common triggers of asthma exacerbation. Antibiotics were used in 80.0%, bronchodilators in 66.0%, inhaled corticosteroid in 64.0%. A peak flow meter for monitoring lung function was used in 17% of asthmatic children over 5 years old. Conclusion The prevalence of asthma is associated with age and gender in children aged 0-14 years old in Kunming City. Acute asthma attack occurs mostly in winter and at midnight or dawn. Respiratory tract infection is the most common trigger of asthma exacerbation. Nearly a half of patients with asthma had not been diagnosed with asthma in the early stage. Most asthmatic children use antibiotics and only two-thirds use bronchodilators or inhaled corticosteroid in the treatment. The treatment and management of asthma in children awaits improvement as well.
2014 Vol. 16 (9): 910-913 [Abstract] ( 5962 ) [HTML 1KB] [PDF 1131KB] ( 1256 )
914 ZHAO Hong-Mei, YOU Jie-Yu, XU Bin, DUAN Bo-Ping, YE Hong, REN Chun-Chun, LIU Li, CHEN Zhi-Yong
Clinical characteristics of infants with allergic proctocolitis：a retrospective study of 96 cases
Objective To study the clinical characteristics of hospitalized infants with allergic proctocolitis, and to provide a scientific basis for early diagnosis and effective treatment of allergic proctocolitis. Methods The clinical data of 96 infants with allergic proctocolitis between September 2011 and March 2013 were reviewed retrospectively.Descriptive analysis was performed to assess the clinical characteristics of allergic proctocolitis. Results The most common clinical manifestation was diarrhea in the 96 infants. The electronic colonoscopy results indicated that 40% of the infants had multiple small nodules, 26% showed focal erythema and brittle mucous membranes, 25% showed multiple superficial erosion, and 9% showed ulcers with surface exudates. The affected areas included the sigmoid colon（87%), rectum（24%), descending colon（13%), and transverse colon ascending colon and ileocecal junction（8%). Histopathologic examination showed eosinophilic infiltration of mucosal layers, the condition of which was mild to moderate in 89% and severe and extremely severe in 12% of the infants. To treat the allergic proctocolitis, mothers and infants were suggested to avoid allergenic foods; 43% of them continued breastfeeding, 45% switched to highly hydrolyzed protein formula, and 13% were prescribed amino acid-based elemental formula. All infants were in complete remission at discharge. Conclusion As the clinical manifestations of allergic proctocolitis in infants lack specificity, the electronic colonoscopy and mucosal histopathologic examination are helpful for early and differential diagnosis. The best treatment is to avoid allergenic foods. Formula-feeding infants should be prescribed highly hydrolyzed protein formula or amino acid-based elemental formula.
2014 Vol. 16 (9): 914-918 [Abstract] ( 5503 ) [HTML 1KB] [PDF 1583KB] ( 1503 )
919 HU Jian-Fen, WU Jiang-Yan, ZHANG Lin, YANG Long-Gui, LONG Cai-Xia
Diagnostic value of high mobility group box 1 for acute appendicitis in children
Objective To evaluate the value of high mobility group box 1(HMGB1) in the diagnosis of pediatric acute appendicitis. Methods The children with acute abdomen who had a diagnosis of suspected acute appendicitis between January and July 2013 and 25 healthy children were enrolled in this study. Serum HMGB1 levels were measured using ELISA on admission. The patients were classified into 2 groups according to surgery confirmation or pathological results: appendicitis（n=28) and non-appendicitis（n=35). Results Serum HMGB1 levels and WBC in the appendicitis and non-appendicitis groups were significantly higher than in the healthy children group（P<0.01). The appendicitis group showed more increased serum HMGB1 levels compared with the non-appendicitis group（median: 32.9 ng/mL vs 22.0 ng/mL; P<0.01). For a diagnosis of acute appendicitis, the sensitivity and specificity of serum HMGB1 was 71.4% and 82.9% respectively at the best cutoff of 28.0 ng/mL, with the accuracy of 77.8% and the area under the curve of 0.765（95%CI 0.638-0.893). Conclusion HMGB1 may play a role in the diagnosis of pediatric acute appendicitis.
2014 Vol. 16 (9): 919-921 [Abstract] ( 5535 ) [HTML 1KB] [PDF 1106KB] ( 954 )
EXPERIMENTAL RESEARCH
922 CAI Xiao-Fang, SUN Ji-Min, LI Wen-Bin
Effect of hyperoxia on p53 and PCNA expression in fetal rat lung fibroblasts
Objective To study the effect of hyperoxia exposure on the expression of p53 and proliferating cell nuclear antigen（PCNA) in fetal rat lung fibroblasts（LFs). Methods Primary rat embryonic LFs were cultured in vitro.LFs grew to subconfluence and then were randomly divided into air and hyperoxia exposure（95% O2, 5% CO2) groups.After LFs were cultured for 12 and 24 hours, the proliferation was analyzed by MTT. p53 mRNA level was detected by semi-quantitative reverse transcription polymerase chain reaction（RT-PCR). p53 and PCNA protein levels were determined by Western blot. Results After 12 and 24 hours of culture the growth inhibition rate of LFs was 8% and 23% respectively in the hyperoxia exposure group. p53 mRNA and protein levels increased significantly（P<0.01) in the hyperoxia exposure group after 12 and 24 hours of culture compared with the air exposure group. Hyperoxia exposure decreased PCNA expression after 24 hours of culture（P<0.01). Conclusion Hyperoxia exposure increases p53 level and decreases PCNA expression, resulting in inhibitions of LFs proliferation and DNA repair.
2014 Vol. 16 (9): 922-926 [Abstract] ( 5231 ) [HTML 1KB] [PDF 1419KB] ( 1107 )
927 ZHANG De-Shuang, BAI Xiao-Hong, CHEN Da-Peng, MU De-Zhi, CHEN Juan
Intracerebral transplantation of human umbilical cord-derived mesenchymal stem cells in neonatal rat model of hypoxic-ischemic brain damage: protective effect to injured brain
Objective To study the brain protection and the possible mechanism of human umbilical cord-derived mesenchymal stem cells（hUC-MSCs) in neonatal rat model of hypoxic-ischemic brain damage（HIBD). Methods Successfully establishing a neonatal rat model of HIBD, hUC-MSCs labeled with BrdU were transplanted into the lateral ventricle 24 hours after HIBD. The number of apoptotic cells and the expression of Caspase-3 were detected by TUNEL and Western blot respectively at 24 and 48 hours after transplantation. The neurological functions of HIBD rats were evaluated by Longa score, and the survival, differentiation and pro-differentiation effects of hUC-MSCs were identified by immunofluorescence at 1 to 3 weeks after transplantation. Results At 24 and 48 hours after transplantation, apoptotic cells and Caspase-3 expression in the MSCs group were less than in the HIBD group（P<0.05). At 2 and 3 weeks after transplantation, the Longa score in the MSCs group was lower than in the HIBD group（P<0.05). After transplantation, positive cells labeled with BrdU were seen in the brain tissue. The expression levels of glial fibrillary acidic protein（GFAP) and neuron specific esterase（NSE) in the MSCs group were higher than in the HIBD and sham-operated control groups（P<0.05), and increased gradually with the transplantation time（P<0.05). Conclusion hUC-MSCs transplantation in HIBD rats can inhibit Caspase-3 expression and reduce apoptotic cells in the early stage, and in the later period, the survival hUC-MSCs can differentiate into neural-like cells and promote the differentiation of endogenous neural-like cells, providing protective effects to brain.
2014 Vol. 16 (9): 927-932 [Abstract] ( 5316 ) [HTML 1KB] [PDF 2903KB] ( 1355 )
933 FAN Yu-Ying, YU Tao, ZHANG Jun-Mei, WANG Hua, ZHAO Gui-Feng, LIU Bo
Expression of endogenous leukemia inhibitory factor in neonatal rats with periventricular leukomalacia
Objective To study the changes of endogenous leukemia inhibitory factor（LIF) in neonatal rats with periventricular leukomalacia（PVL). Methods A PVL model of 3-day-old Wistar rats was prepared by left carotid artery ligation followed by 6% oxygen for 4 hours. The rats were sacrificed at 1, 3, 7, 14 and 28 days of hypoxia ischemia（HI), and the brain tissues were sampled. Real-Time PCR and Western blot methods were applied to analyze the expression of LIF mRNA and protein. Double staining immunofluorescence was used to detect the co-expression of LIF and GFAP. Results At 1, 3 and 7 days of HI, LIF protein level in the PVL group was higher than in the control group（P<0.01). In the PVL group, the LIF protein level on the third day after HI reached a peak and was higher than the other time points（P<0.01). The change of LIF mRNA expression showed the same tendency with LIF protein. The double staining immunofluorescence showed a co-expression of LIF and GFAP. Conclusion LIF mRNA and LIF protein expression in astrocytes show a trend of initial increase followed by steady decline in neonatal rats with PVL, suggesting that endogenous LIF may participate in the repair of PVL.
2014 Vol. 16 (9): 933-938 [Abstract] ( 5384 ) [HTML 1KB] [PDF 3338KB] ( 1006 )
939 WANG Yan-Mei, WU Jian-Rong, TIAN Song-Bai, LI Shan-Shan, GU Qiang
Roles of type II 11β-hydroxysteroid dehydrogenase and its signaling factors in pathogenesis of persistent pulmonary hypertension in neonatal rats
Objective To study the roles of type II 11β-hydroxysteroid dehydrogenase（11β-HSD2) and it's signaling factors in the lung tissue in pathogenesis of persistent pulmonary hypertension（PPH) in neonatal rats.Methods Six Sprague-Dawley rats on the 19th day of pregnancy were randomly divided into PPH and control groups（n=3 each). The PPH group was intraperitoneally injected with indomethacin（0.5 mg/kg) twice daily and exposed in 12% oxygen for three days, in order to prepare a fetal rat model of PPH. The control group was intraperitoneally injected with an equal volume of normal saline and exposed to air. Neonatal rats were born by caesarean section from both groups on the 22nd day of pregnancy. In each group, 15 neonatal rats were randomly selected and sacrificed. 11β-HSD2 expression in the lung tissue of neonatal rats were observed by Confocal laser technology, and serum cortisol levels and prostacyclin, renin, angiotensin and aldosterone in the lung tissue of both groups were measured using ELISA. Results 11β-HSD2 protein was widely expressed in the lung tissue of the control and PPH groups. The levels of 11β-HSD2 and prostacyclin in the lung tissue were lower in the PPH group than in the control group, while serum cortisol levels and renin, angiotensin and aldosterone in the lung tissue were higher in the PPH group than in the control group（P<0.05).Conclusion 11β-HSD2 and it's signaling factors play roles in pathogenesis of PPH in neonatal rats.
2014 Vol. 16 (9): 939-943 [Abstract] ( 5506 ) [HTML 1KB] [PDF 2798KB] ( 1745 )
CLINICAL EXPERIENCE
944 ZHANG Yong-Hong, WANG Jun, ZHU Ying, et al
Effectiveness of inhibited nitric oxide combined with oral sildenafil for the treatment of serious congenital diaphragmatic hernia

No abstract available
2014 Vol. 16 (9): 944-946 [Abstract] ( 4222 ) [HTML 1KB] [PDF 1032KB] ( 1083 )
CASE REPORT
947 ZHANG Yi-Ning, Palati REHEMAN, DU Hong-Wei, et al
Growth hormone deficiency in a girl with ring 18 chromosome syndrome

No abstract available
2014 Vol. 16 (9): 947-948 [Abstract] ( 4768 ) [HTML 1KB] [PDF 967KB] ( 1321 )
949 LUO Kai-Ju, CHEN Ping-Yang, LI Wen
DiGeorge syndrome in a neonate

No abstract available
2014 Vol. 16 (9): 949-951 [Abstract] ( 4924 ) [HTML 1KB] [PDF 1642KB] ( 1525 )
952 CHENG Chao, ZHANG Xue-Yuan, LI Jiu-Jun
Primary carnitine deficiency in an infant

No abstract available
2014 Vol. 16 (9): 952-954 [Abstract] ( 4484 ) [HTML 1KB] [PDF 1054KB] ( 1243 )
955 YE Qi-Dong, WANG Xiang, MIAO Yan, et al
Increased B-lymphocyte prognitor cells in a boy with acute lymphoblastic leukemia after chemotherapy

No abstract available
2014 Vol. 16 (9): 955-956 [Abstract] ( 4309 ) [HTML 1KB] [PDF 1163KB] ( 1274 )
REVIEW
957 REN Yuan-Yuan, ZHU Xiao-Fan
Research progress in molecular biology of pediatric myelodysplastic syndrome
Marked differences have been found in molecular characteristics between pediatric and adult myelodysplastic syndrome（MDS) patients. The incidence of gene mutations associated with myeloid malignances in pediatric patients is lower than in adults, while the incidence of aberrant methylation is similar between them. It is also worth noting that novel molecular factors such as mitochondrial DNA mutations may play a role in the pathogenesis of childhood MDS. This article summarizes research advances in molecular biology of pediatric MDS.
2014 Vol. 16 (9): 957-961 [Abstract] ( 5983 ) [HTML 1KB] [PDF 1281KB] ( 1167 )
962 LIU Hai-Ting, MU De-Zhi
Inducible nitric oxide synthase and brain hypoxic-ischemic brain damage
Brain hypoxia-ischemia has been considered as critical factors in many human central nervous system diseases, including stroke and neonatal hypoxic-ischemic encephalopathy. In brain hypoxia-ischemia processes, inducible NO synthase（iNOS) is induced to produce excessive nitric oxide（NO) which leads to cascade reactions of inflammation and neuronal death, deteriorating primary brain injury. Inhibiting iNOS expression has opened new perspectives in the treatment of brain hypoxia-ischemia because iNOS inhibitor has been shown as a potent therapeutic agent. This reviews focus on recent research achievements regarding the relationship between iNOS and ischemic-hypoxic brain damage and the perspective of using iNOS inhibitors as therapeutic strategies for brain ischemic-hypoxic brain damage.
2014 Vol. 16 (9): 962-967 [Abstract] ( 6052 ) [HTML 1KB] [PDF 1392KB] ( 1445 )
CJCP
About Journal
Editors members
Contact Us

 
Copyright © 2004-2005 Chinese Journal Of Contemporary Pediatrics All rights reserved.
Addr: 87 Xiangya Road, Changsha, Hunan, 410008, PRC
Tel: 0731-84327402 Fax: 0731-84327922 E-mail: cjcp1999@csu.edu.cn