Effect of oral administration of probiotics on intestinal colonization with drugresistant bacteria in preterm infants

HUA Xin-Tian; TANG Jun; MU De-Zhi

doi:10.7499/j.issn.1008-8830.2014.06.009

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (6) : 606-609. DOI: 10.7499/j.issn.1008-8830.2014.06.009

CLINICAL RESEARCH

Effect of oral administration of probiotics on intestinal colonization with drugresistant bacteria in preterm infants

HUA Xin-Tian, TANG Jun, MU De-Zhi

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Department of Neonatology, West China Second University Hospital, Sichuan University. Chengdu 610041, China

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Abstract

Objective To evaluate the effect of oral administration of probiotics on intestinal colonization with drug-resistant bacteria among preterm infants in the neonatal intensive care unit (NICU). Methods A doubleblind, randomized, placebo-controlled trial was carried out in the preterm infants who were transferred to the NICU immediately after birth. These infants were stratified by whether they were breastfed and then randomized into test group and control group. The test group was given probiotics from the day when enteral feeding began, while the control group was treated conventionally without probiotics. The two groups were compared in terms of the colonization with extended-spectrum beta-lactamase-producing bacteria, as assessed by rectal swabs on days 1, 3, 7, and 14 after birth, and the incidence of diseases. Results Rectal colonization with drug-resistant bacteria was found in the test group (n=119) and control group (n=138) on days 1, 3, 7, and 14 after birth. There were no significant differences in the incidence of late-onset sepsis and necrotizing enterocolitis between the two groups (P>0.05). Among non-breastfed infants, the test group had significantly decreased rectal colonization with drug-resistant bacteria compared with the control group on day 14 after birth (71.1% vs 88.9%; P=0.04). No probiotic-related adverse events were observed in the study. Conclusions Oral administration of probiotics may reduce rectal colonization with drug-resistant bacteria in preterm infants under certain conditions and shows good safety.

Key words

Probiotics / Drug-resistant bacteria / Colonization / Preterm infant

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HUA Xin-Tian, TANG Jun, MU De-Zhi. Effect of oral administration of probiotics on intestinal colonization with drugresistant bacteria in preterm infants[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(6): 606-609 https://doi.org/10.7499/j.issn.1008-8830.2014.06.009